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In 2003 we started the Retriever Program based on novel, unique antigen unmasking automatic unit.
The number of Retrievers worldwide is constantly growing. It is in prectically all countries and continents turning into something like international standard for antigen unmasking. If you are considering whether to acquire your own Retriever, please see some of the experiments done with it in various types of research and clinical studies.
We present here only some examples that best illustrate what you can do with this machine and why hudreds are using it.
Some reference, for convininece divided according to the field of research are below. By clicking on the icon of the journal you can access the publication itself.
Cell biology
Cancer Pathology
Immunology, Research & Clinical
Virology & Microbiology
Neurosciences
Dermatology
Reproductiove Biology
| How people use Retriever
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Cell Biology, Developmantal Biology
& Mouse Models |  |
Molecular Biology of the Cell Vol. 20, 2572–2581, May 15, 2009
Regulation of Mammary Gland Branching Morphogenesis
by EphA2 Receptor Tyrosine Kinase David Vaught, Jin Chen, and Dana M. Brantley-Sieders
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Mol Cancer Ther. 2008 Mar;7(3):590-8
Dual inhibition of VEGFR and EGFR signaling reduces the
incidence and size of intestinal adenomas in Apc(Min/+) mice.
Alferez D, Wilkinson RW, Watkins J, Poulsom R, Mandir N,
Wedge SR, Pyrah IT, Smith NR, Jackson L, Ryan AJ, Goodlad RA.
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Mol Cell Biol. 2004 Apr;24(7):2673-81.
Inhibition of Mist1 homodimer formation induces pancreatic
acinar-to-ductal metaplasia.
Zhu L, Tran T, Rukstalis JM, Sun P, Damsz B, Konieczny SF.
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Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10063-8
Loss of a quiescent niche but not follicle stem cells in the
absence of bone morphogenetic protein signaling.
Kobielak K, Stokes N, de la Cruz J, Polak L, Fuchs E.
|  | Science. 2010 Jun 4;328(5983):1278-81.
Meiotic recombination provokes functional activation of the
p53 regulatory network.
Lu WJ, Chapo J, Roig I, Abrams JM.
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Cancer Res. 2006 Jan 1;66(1):242-7.
Mist1-KrasG12D knock-in mice develop mixed differentiation
metastatic exocrine pancreatic carcinoma and hepatocellular carcinoma.
Tuveson DA, Zhu L, Gopinathan A, Willis NA, Kachatrian L,
Grochow R, Pin CL, Mitin NY, Taparowsky EJ, Gimotty PA, Hruban RH, Jacks T,
Konieczny SF.
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J Clin Invest. 2008 Jan;118(1):89-99.
Glypican-1 modulates the angiogenic and metastatic potential of human
and mouse cancer cells.
Aikawa T, Whipple CA, Lopez ME, Gunn J, Young A, Lander AD, Korc M.
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Cancer Res. 2007 Jan 1;67(1):276-80.
Transgenic overexpression of RasGRP1 in mouse epidermis
results in spontaneous tumors of the skin.
Oki-Idouchi CE, Lorenzo PS.
| Cancer Pathology
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Urology. 2006 Sep;68(3):578-82.
Inactivation of myopodin expression associated with prostate
cancer relapse.
Yu YP, Tseng GC, Luo JH.
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Acta Oncol. 2008;47(8):1539-45.
Aberrant expression of cyclin E in low-risk node negative
breast cancer.
Ahlin C, Gruhne B, Holmqvist M, Zetterberg A, Fjällskog ML.
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Breast Cancer Res Treat. 2010 Jul;122(2):315-24.
Numb protein expression correlates with a basal-like
phenotype and cancer stem cell markers in primary breast cancer.
Rennstam K, McMichael N, Berglund P, Honeth G, Hegardt C,
Rydén L, Luts L, Bendahl PO, Hedenfalk I.
|  | Pancreas. 2009 Apr;38(3):259-66.
Neurogenin 3 and neurogenic differentiation 1 are retained
in the cytoplasm of multiple endocrine neoplasia type 1 islet and pancreatic
endocrine tumor cells.
Lejonklou MH, Edfeldt K, Johansson TA, Stålberg P, Skogseid
B.
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Horm Metab Res. 2008 May;40(5):354-9.
Lack of nuclear expression of hairy and enhancer of split-1
(HES1) in pancreatic endocrine tumors.
Johansson T, Lejonklou MH, Ekeblad S, Stålberg P, Skogseid
B. |  | Leuk Lymphoma. 2010 Jul;51(7):1269-77.
Potential biomarkers of bortezomib activity in mantle cell
lymphoma from the phase 2 PINNACLE trial.
Goy A, Bernstein SH, McDonald A, Pickard MD, Shi H, Fleming
MD, Bryant B, Trepicchio W, Fisher RI, Boral AL, Mulligan G.
|  | Clin Cancer Res. 2006 Jul 1;12(13):4080-9.
PHA-680632, a novel Aurora
kinase inhibitor with potent antitumoral activity.
Soncini C, Carpinelli P, Gianellini L, Fancelli D, Vianello
P, Rusconi L, Storici P, Zugnoni P, Pesenti E, Croci V, Ceruti R, Giorgini ML,
Cappella P, Ballinari D, Sola F, Varasi M, Bravo R, Moll J.
| Immunology, Research & Clinical
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J Exp Med. 2009 Aug 3;206(8):1661-71.
Loss of the lupus autoantigen Ro52/Trim21 induces tissue
inflammation and systemic autoimmunity by disregulating the IL-23-Th17 pathway.
Espinosa A, Dardalhon V, Brauner S, Ambrosi A, Higgs R,
Quintana FJ, Sjöstrand M, Eloranta ML, Ní Gabhann J, Winqvist O, Sundelin B,
Jefferies CA, Rozell B, Kuchroo VK, Wahren-Herlenius M.
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Bone Marrow Transplant. 2008 Dec;42(12):807-18.
GVHD after chemotherapy conditioning in allogeneic
transplanted mice.
Sadeghi B, Aghdami N, Hassan Z, Forouzanfar M, Rozell B,
Abedi-Valugerdi M, Hassan M.
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J Reprod Immunol. 2010 Mar;84(2):176-85.
Pro-inflammatory and anti-inflammatory cytokines in human
preterm and term cervical ripening.
Dubicke A, Fransson E, Centini G, Andersson E, Byström B,
Malmström A, Petraglia F, Sverremark-Ekström E, Ekman-Ordeberg G.
| Virology and Microbiology
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Virology. 2009 Oct 25;393(2):338-45.
An early 'classical' swine H1N1 influenza virus shows
similar pathogenicity to the 1918 pandemic virus in ferrets and mice.
Memoli MJ, Tumpey TM, Jagger BW, Dugan VG, Sheng ZM, Qi L,
Kash JC, Taubenberger JK.
|  | mBio 2010 1(1):e00067-10. doi:10.1128
The PB2-E627K mutation attenuates viruses containing the 2009 H1N1 influenza pandemic polymerase.
Jagger, B. W., M. J. Memoli, Z.-M. Sheng, L. Qi, R. J. Hrabal, et al.
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PLoS One. 2009 Jun 16;4(6):e5916.
Infectious prions in pre-clinical deer and transmission of
chronic wasting disease solely by environmental exposure.
Mathiason CK, Hays SA, Powers J, Hayes-Klug J, Langenberg J,
Dahmes SJ, Osborn DA, Miller KV, Warren RJ, Mason GL, Hoover EA.
|  | J Virol. 2009 Apr;83(8):3754-61.
Role of sialic acid binding specificity of the 1918 influenza virus hemagglutinin protein in virulence and pathogenesis for mice.
Qi L, Kash JC, Dugan VG, Wang R, Jin G, Cunningham RE, Taubenberger JK.
| Neurosciences
|  | J Comp Neurol. 2008 Sep 1;510(1):79-99.
Distinct molecular pathways for development of telencephalic
interneuron subtypes revealed through analysis of Lhx6 mutants.
Zhao Y, Flandin P, Long JE, Cuesta MD, Westphal H,
Rubenstein JL.
| Dermatology
|  | Journal of Investigative Dermatology (2005) 124, 615–621
Mutations in Gasdermin 3 Cause Aberrant Differentiation of the Hair Follicle and Sebaceous Gland
Declan P Lunny, Erica Weed, Patrick M Nolan, Andreas Marquardt, Martin Augustin and Rebecca M Porter
| Reproductive Biology & Endocriniligy
|  | Fertility & Sterility. Vol 91, Issue 4, Supplement, Pages 1420-1423 (April 2009)
Expressions of steroid receptors and Ki67 in first-trimester decidua and chorionic villi exposed to levonorgestrel used for emergency contraception
Chun-Xia Meng, M.D.ab, Li-Nan Cheng, M.D.b, Parameswaran Grace Luther Lalitkumar, Ph.D.a, Lin Zhang, M.D.b, Hui-Juan Zhang, M.D.b, Kristina Gemzell-Danielsson, M.D., Ph.D.
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Hum Reprod. 2010 Apr;25(4):874-83.
Effects of oral and vaginal administration of levonorgestrel
emergency contraception on markers of endometrial receptivity.
Meng CX, Marions
L, Byström B, Gemzell-Danielsson K.
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