 |  |
 |
| Groups of Antibodies |
 |
|
Inroduction. PickCell Laboratories BV is developing antibodies to a new antigenic markers for human, animal and viral antigens. For your orientation here is a brief description of what had being placed into every group |
NEW ANTIBODY RELEASES
Lamins
Reticulon RTN1 (NSPs)
Nestin
Smoothelein
Plakophilin
Internexin
Aquaporin 2
|
Human Pathology
Antibodies for staining antigens of the normal and diseased cells for differential diagnostic and disease prognostic research. Most are for use on routine paraffin-embedded tissues. |
Mouse & Rat Histology
Antibodies to tissue and cell type markers of mouse tissues. Can be used on routinely fixed tissues. |
Human or Mouse CD Markers
Pure and conjugated antibodies for frozen tissues and flow cytometry |
| Antibodies for Assays for Viruses, Bacteria, Toxins. These antibodies are usually represented by several antibodies of different isotype and/or specificity. |
Secondary antibodies
Enzyme, Biotin or fluorescein labelled antibodies to various animal immunoglobulins. Recommended for immunohistochemistry and flow cytometry, as well as other immunoassays |
Lamins
Nuclear lamins form a network of filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2 |
| h |
#15205 |
Lamin A (LMNA) |
Price* |
| Mouse mAb |
IgG3 |
Clone: 133A2 |
Reacts exclusively with Lamin A, with epitope located between residues 598-611 |
EUR |
USD |
| Freeze-Dried |
100 mcg |
Methods: IHC-F, WB-R/NR, FC; IHC-P expected but not tested |
155.- |
180.- |
| hh |
#15206 |
Lamins A & C (LDP1; LMN1; LMNC; PRO1; LMNA) |
Price* |
| Mouse mAb |
IgG1 |
Clone: 131C3 |
Reacts with both forms, epitope at position 319-566 |
EUR |
USD |
| Freeze-Dried |
100 mcg |
Methods: IHC-F, WB, FC |
155.- |
180.- |
| hh |
#15207 |
Lamin B1 (LMNB1) |
Price* |
| Mouse mAb |
IgG1 |
Clone: 119D5 |
C-terminal epitope, reacts with B1 only |
EUR |
USD |
| Freeze-Dried |
100 mcg |
Methods: IHC-F, WB, FC |
155.- |
180.- |
| hh |
#15208 |
Lamin B2 (LMNB2) |
Price* |
| Mouse mAb |
IgG1 |
Clone: LN43 |
For cell biology and histology studies, as wel as histology. |
EUR |
USD |
| Freeze-Dried |
100 mcg |
Methods: IHC-F, WB, FC |
155.- |
180.- |
Reticulon RTN1 (NSPs)
Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. Alternatively spliced transcript variants encoding different isoforms have been identified. Multiple promoters rather than alternative splicing of internal exons seem to be involved in this diversityfamily was designated the NSP-gene (Neuroendocrine-Specific-Protein gene), because Northern blot analysis indicated that it is specifically expressed in neural and neuroendocrine tissues. Proteins that are selectively expressed in neural and endocrine cells are of interest as discriminating markers in cell typing during biological development as well as in differential diagnosis of tumors in general and of lung carcinomas in particular. |
| b |
#15333 |
NSP A (Reticulon 1 isoform A; RTN-1A) |
Price* |
| Mouse mAb |
IgG1 |
Clone: Mon160 |
Neuro-endocrine specific protein (NSP)-A. This antibody is reactive with residues 174-337. |
EUR |
USD |
| Freeze-Dried |
100 mcg |
Methods: IHC-P, IHC-F, WB, FC |
155.- |
180.- |
| b |
#15335 |
NSP A (Reticulon 1 isoform A; RTN-1A) |
Price* |
| Mouse mAb |
IgG1 |
Clone: Mon162 |
Neuro-endocrine specific protein (NSP)-A. This antibody is reactive with residues 338-422. |
EUR |
USD |
| Freeze-Dried |
100 mcg |
Methods: IHC-P, IHC-F, WB, FC |
155.- |
180.- |
| b |
#15337 |
NSP A and B (Reticulon 1, both isoforms) |
Price* |
| Mouse mAb |
IgG1 |
Clone: RNL2 |
Antibody prepared against small cell lung cancer cell line. The exact epitope unknown. |
EUR |
USD |
| Freeze-Dried |
100 mcg |
Methods: IHC-F, WB, FC |
155.- |
180.- |
| b |
#15338 |
NSP C (Reticulon 1 isoform A; RTN-1A) |
Price* |
| Mouse mAb |
IgG1 |
Clone: RNL4 |
Prepared against the amino-terminal sequence of the molecule. |
EUR |
USD |
| Freeze-Dried |
100 mcg |
Methods: IHC-P, IHC-F, WB, FC |
155.- |
180.- |
Nestin
Nestin is a Class IV intermediate filament protein abundantly produced in the developing central nervous system (CNS) and in early embryonic neuroepithelial stem cells. This cytoskeletal protein has been widely used as a predominant marker for stem/progenitor cells, glioma cells, and tumor endothelial cells. Also, it is a superior angiogenic marker to evaluate neovascularity of endothelial cells in tumors.
|
| b |
#15222 |
Nestin |
Price* |
| Mouse mAb |
IgG1 |
Clone: 10C2 |
Widely used marker for stem cells, glioma cells and tumor endothelial cells (angiogenic marker) |
EUR |
USD |
| Freeze-Dried |
100 mcg |
Methods: IHC-P, IHC-F, WB, FC |
155.- |
180.- |
Smoothelein
Smoothelin is a constituent of the smooth muscle cell (SMC) cytoskeleton. Antibodies directed to smoothelin are a useful tool to monitor SMC differentiation. The monoclonal smoothelin antibody R4A is useful to discriminate fully differentiated, contractile SMCs from proliferative SMCs. The distribution of smoothelin-positive cells indicates a correlation between smoothelin expression and smooth muscle tissue contractility. Smoothelin is a useful tool in the evaluation of atherosclerotic lesions. |
| b |
#15342 |
Smoothelein, Human |
Price* |
| Mouse mAb |
IgG1 |
Clone: R4A |
Reacts with the 59 kDa and 100 kDa protein, corresponding to smoothelin A and B, respectively.. |
EUR |
USD |
| Freeze-Dried |
100 mcg |
Methods: IHC-P, IHC-F, WB, FC |
155.- |
180.- |
Plakophilin
Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways. |
| b |
#15340 |
Plakophilin 3, Human |
Price* |
| Mouse mAb |
IgG2b |
Clone: 23E3 |
Reacts with epitope 570-589 in human plakophilin-3 |
EUR |
USD |
| Freeze-Dried |
100 mcg |
Methods: IHC-P, IHC-F, WB-NR, FC |
155.- |
180.- |
NF66/ alpha-Internexin
Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways. |
| b |
#15220 |
Internexin Human |
Price* |
| Mouse mAb |
IgG1 |
Clone: 2E3 |
For cell biology and histology studies, as wel as histology. |
EUR |
USD |
| Freeze-Dried |
100 mcg |
Methods: IHC-P, IHC-F, WB, FC |
155.- |
180.- |
Aquaporin 2
A water channel protein located in the kidney collecting tubule. It belongs to the MIP/aquaporin family. |
| b |
#15343 |
Aquaporin 2 (APN2; AQP-CD; WCH-CD) |
Price* |
| Mouse mAb |
IgG1 |
Clone:
E13- 21 |
Antibody is directed against C-terminal sequence of Aquaporin 2 |
EUR |
USD |
| Freeze-Dried |
100 mcg |
Methods: IHC-P, IHC-F, WB-NR, IP-NR, FC |
155.- |
180.- |
|
|
|